Coordination-driven self-assembly of ruthenium(ii) architectures: synthesis, characterization and cytotoxicity studies

Abstract

Coordination-driven self-assembly of organometallic η⁶-arene ruthenium(II) supramolecular architectures (MA₁–MA₄) was carried out by employing dinuclear ruthenium acceptors [Ru₂(μ-η⁴-C₂O₄)(CH₃OH)₂(η⁶-p-cymene)₂](CF₃SO₃)₂ (Ru_a), [Ru₂(μ-η⁴-C₆H₂O₄)(CH₃OH)₂(η⁶-p-cymene)₂](CF₃SO₃)₂ (Ru_b), [Ru₂(dhnq)(H₂O)₂(η⁶-p-cymene)₂](CF₃SO₃)₂ (Ru_c) and [Ru₂(dhtq)(H₂O)₂(η⁶-p-cymene)₂](CF₃SO₃)₂ (Ru_d) separately with a new tetratopic donor (TD) in methanol at room temperature [TD = N,N,N′,N′-tetra(pyridin-4-yl)-[1,1′-biphenyl]-4,4′-diamine]. All the coordination architectures were characterized by using spectroscopic techniques. The potency of these self-assembled architectures against human cervical cancer HeLa and human lung adenocarcinoma A549 cell lines is explored in vitro using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), annexin V-FITC/PI and 2′,7′-dichlorofluorescein-diacetate assays.