Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

Lai-Hon Chung; Sze-Wing Ng; Chi-Fung Yeung; Hau-Lam Shek; Sheung-Ying Tse; Hoi-Shing Lo; Siu-Chung Chan; Man-Kit Tse; Shek-Man Yiu; Chun-Yuen Wong

doi:10.1039/C8DT02408A

Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application†

Lai-Hon Chung,

‡^a Sze-Wing Ng,

‡^ab Chi-Fung Yeung,

^abc Hau-Lam Shek,

^a Sheung-Ying Tse,

^a Hoi-Shing Lo,

^ac Siu-Chung Chan,

^a Man-Kit Tse,

^a Shek-Man Yiu

^a and Chun-Yuen Wong

*^abc

Author affiliations

* Corresponding authors

^a Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR
E-mail: acywong@cityu.edu.hk

^b State Key Laboratory of Millimeter Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR

^c Shenzhen Research Institute, City University of Hong Kong, Shenzhen, P. R. China

Abstract

The two series of ruthenium–indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental–theoretical investigation suggests an unconventional 5-endo-dig cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.

Dalton Transactions

Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application†

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Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

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