H2O2-mediated metal-free protocol towards unsymmetrical thiosulfonates from sulfonyl hydrazides and disulfides in PEG-400

Zhihong Peng; Xiao Zheng; Yingjun Zhang; Delie An; Wanrong Dong

doi:10.1039/C8GC00381E

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H₂O₂-mediated metal-free protocol towards unsymmetrical thiosulfonates from sulfonyl hydrazides and disulfides in PEG-400†

Zhihong Peng,^a Xiao Zheng,^a Yingjun Zhang,^b Delie An*^a and Wanrong Dong

*^a

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* Corresponding authors

^a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Lushan South Rd. 2, Changsha, P.R. China
E-mail: deliean@hnu.edu.cn, wanrongdong@hnu.edu.cn

^b State Key Laboratory of Anti-Infective Drug Development (NO. 2015DQ780357), Sunshine Lake Pharma Co., Ltd, Dongguan, P.R. China

Abstract

A green and practical protocol between sulfonyl hydrazides and disulfides is herein reported for the synthesis of unsymmetrical thiosulfonates with the assistance of H₂O₂ in PEG-400, releasing N₂ and H₂O as the byproducts. The efficient and compatible process was considered to take place in the absence of metallic catalysts through a radical mechanism as determined by EPR analysis.

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Article information

DOI: https://doi.org/10.1039/C8GC00381E
Article type: Communication
Submitted: 03 Feb 2018
Accepted: 21 Mar 2018
First published: 21 Mar 2018

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Green Chem., 2018,20, 1760-1764

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H₂O₂-mediated metal-free protocol towards unsymmetrical thiosulfonates from sulfonyl hydrazides and disulfides in PEG-400

Z. Peng, X. Zheng, Y. Zhang, D. An and W. Dong, Green Chem., 2018, 20, 1760 DOI: 10.1039/C8GC00381E

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