A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

Wenjun Li; Dongyuan Wang; Xiaodong Shi; Jingxu Li; Yue Ma; Yanding Wang; Tingting Li; Jianing Zhang; Rongtong Zhao; Zhiqiang Yu; Feng Yin; Zigang Li

doi:10.1039/C8MH00392K

A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy†

Wenjun Li,^a Dongyuan Wang,^a Xiaodong Shi,^a Jingxu Li,^a Yue Ma,^a Yanding Wang,^a Tingting Li,^b Jianing Zhang,^a Rongtong Zhao,^a Zhiqiang Yu,

^c Feng Yin

*^a and Zigang Li

*^a

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* Corresponding authors

^a State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
E-mail: lizg@pkusz.edu.cn
Fax: +86-755-2603-3174
Tel: +86-755-2603-3616

^b School of Advanced Material, Peking University Shenzhen Graduate School, Shenzhen, China

^c School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China

Abstract

Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo. In a tumor xenograft nude mouse model, these siRNA–peptide nanospheres inhibited tumor volume growth by >60%.

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A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy†

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A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

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