Issue 11, 2018

Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug

Abstract

Arsenic trioxide (ATO) is used in the clinic for the treatment of acute promyelocytic leukemia by targeting the protein PML. However, many zinc-finger proteins could also be reactive to arsenic in cells. Here we found that ATO preferentially binds to the ring-finger domain of PML in a protein mixture with zinc-finger domains. These results provide the molecular basis of the target selection of ATO in cells.

Graphical abstract: Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug

Supplementary files

Article information

Article type
Communication
Submitted
25 Jul 2018
Accepted
18 Sep 2018
First published
19 Sep 2018

Metallomics, 2018,10, 1564-1569

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