Issue 10, 2018
From the journal:

New Journal of Chemistry

Highly antiproliferative neutral Ru(ii)-arene phosphine complexes

Florian Chotard,a   Lucile Dondaine,abc   Cédric Balan,a   Ali Bettaïeb,bc   Catherine Paul,bc   Pierre Le Gendrea  and  Ewen Bodio ORCID logo *a  

* Corresponding authors

a ICMUB UMR6302, CNRS, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France
E-mail: ewen.bodio@u-bourgogne.fr
Tel: +33 3 80 39 60 76

b Laboratoire d'Immunologie et Immunothérapie des Cancers, EPHE, PSL Research University, 75000, Paris, France

c LIIC, EA7269, Université de Bourgogne Franche Comté, 21000, Dijon, France

Abstract

Six ruthenium(II)- and four gold(I)-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru(II) complexes displayed an IC50 of around 2 μM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced.

Graphical abstract: Highly antiproliferative neutral Ru(ii)-arene phosphine complexes

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Article information

DOI
https://doi.org/10.1039/C7NJ04442A
Article type
Paper
Submitted
15 Nov 2017
Accepted
10 Jan 2018
First published
10 Jan 2018

New J. Chem., 2018,42, 8105-8112

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Highly antiproliferative neutral Ru(II)-arene phosphine complexes

F. Chotard, L. Dondaine, C. Balan, A. Bettaïeb, C. Paul, P. Le Gendre and E. Bodio, New J. Chem., 2018, 42, 8105 DOI: 10.1039/C7NJ04442A

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