Issue 8, 2018

A scalable process to produce lipid-based compartmented Janus nanoparticles with pharmaceutically approved excipients

Abstract

In the field of nanotechnologies, theranostic approaches and fixed-dose combination products require the development of innovative carriers able to co-encapsulate several entities of interest. This communication describes the preparation and characterization of lipid-based Janus compartmented nanoparticles. They were successfully prepared using a scalable process with pharmaceutically approved excipients. The analysis of the microscopic structure and supramolecular organization demonstrated the formation of two physico-chemically different compartments enabling the co-administration at once of both liposoluble and hydrosoluble active pharmaceutical ingredients.

Graphical abstract: A scalable process to produce lipid-based compartmented Janus nanoparticles with pharmaceutically approved excipients

Supplementary files

Article information

Article type
Communication
Submitted
14 Nov 2017
Accepted
26 Jan 2018
First published
26 Jan 2018

Nanoscale, 2018,10, 3654-3662

A scalable process to produce lipid-based compartmented Janus nanoparticles with pharmaceutically approved excipients

T. Truong-Cong, E. Millart, L. T. C. Tran, H. Amenitsch, G. Frebourg, S. Lesieur and V. Faivre, Nanoscale, 2018, 10, 3654 DOI: 10.1039/C7NR08488A

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