Issue 13, 2018

Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

Abstract

In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies. Gold surfaces were also covered with the cytotoxic drug rapamycin which was immobilised using a glutathione linker. These nanoconjugates allowed highly specific and efficient delivery of cytotoxic rapamycin into human malignant blood cells.

Graphical abstract: Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

Supplementary files

Article information

Article type
Communication
Submitted
19 Dec 2017
Accepted
02 Feb 2018
First published
14 Mar 2018
This article is Open Access
Creative Commons BY license

Nanoscale, 2018,10, 5827-5833

Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates

I. M. Yasinska, G. Ceccone, I. Ojea-Jimenez, J. Ponti, R. Hussain, G. Siligardi, S. M. Berger, E. Fasler-Kan, M. Bardelli, L. Varani, W. Fiedler, J. Wellbrock, U. Raap, B. F. Gibbs, L. Calzolai and V. V. Sumbayev, Nanoscale, 2018, 10, 5827 DOI: 10.1039/C7NR09436A

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