Issue 23, 2018
From the journal:

Nanoscale

Aptamer-based multifunctional ligand-modified UCNPs for targeted PDT and bioimaging†

Weijia Hou, ORCID logo ‡a   Yuan Liu,‡ab   Ying Jiang,ab   Yuan Wu,ab   Cheng Cui,a   Yanyue Wang,a   Liqin Zhang, ORCID logo a   I-Ting Tenga  and  Weihong Tan ORCID logo *ab  

* Corresponding authors

a Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Health Cancer Center, University of Florida, Gainesville, FL 32611-7200, USA
E-mail: tan@chem.ufl.edu

b Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha, China

Abstract

We designed an aptamer-based multifunctional ligand which, upon conjugation to the surface of upconversion nanoparticles (UCNPs), could realize phase transfer, covalent photosensitizer (PS) loading, and cancer cell targeting in one simple step. The as-built PDT nanodrug is selectively internalized into cancer cells and it exhibits highly efficient and selective cytotoxicity.

Graphical abstract: Aptamer-based multifunctional ligand-modified UCNPs for targeted PDT and bioimaging

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Article information

DOI
https://doi.org/10.1039/C8NR01096J
Article type
Paper
Submitted
06 Feb 2018
Accepted
26 Apr 2018
First published
03 May 2018

Nanoscale, 2018,10, 10986-10990

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Aptamer-based multifunctional ligand-modified UCNPs for targeted PDT and bioimaging

W. Hou, Y. Liu, Y. Jiang, Y. Wu, C. Cui, Y. Wang, L. Zhang, I. Teng and W. Tan, Nanoscale, 2018, 10, 10986 DOI: 10.1039/C8NR01096J

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