Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at the C2 position of the indole moieties via acid-mediated condensation with an aldehyde.
E. Y.-L. Hui, B. Rout, Y. S. Tan, C. S. Verma, K. Chan and C. W. Johannes, Org. Biomol. Chem., 2018, 16, 389 DOI: 10.1039/C7OB02667F
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