B(C6F5)3-catalyzed transfer hydrogenations of imines with Hantzsch esters

Qiaotian Wang; Jingjing Chen; Xiangqing Feng; Haifeng Du

doi:10.1039/C8OB00023A

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B(C₆F₅)₃-catalyzed transfer hydrogenations of imines with Hantzsch esters†

Qiaotian Wang,

^ab Jingjing Chen,^ab Xiangqing Feng*^ab and Haifeng Du

*^ab

Author affiliations

* Corresponding authors

^a Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: fxq@iccas.ac.cn, haifengdu@iccas.ac.cn
Fax: +86-10-62554449
Tel: +86 -10-62652117

^b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

Highly efficient transfer hydrogenations of imines were realized with as low as 0.1 mol% of B(C₆F₅)₃ by using Hantzsch esters as a hydrogen source, furnishing a variety of amines in 80–99% yields. For the asymmetric transfer hydrogenations, up to 38% ee was obtained with chiral diene-derived boron Lewis acids.

This article is part of the themed collection: Synthetic methodology in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB00023A
Article type: Communication
Submitted: 04 Jan 2018
Accepted: 03 Feb 2018
First published: 05 Feb 2018

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Org. Biomol. Chem., 2018,16, 1448-1451

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B(C₆F₅)₃-catalyzed transfer hydrogenations of imines with Hantzsch esters

Q. Wang, J. Chen, X. Feng and H. Du, Org. Biomol. Chem., 2018, 16, 1448 DOI: 10.1039/C8OB00023A

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Organic & Biomolecular Chemistry