Issue 20, 2018

Metal-free photocatalyzed aerobic oxidative Csp3–H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones

Abstract

A metal-free aerobic oxidative dehydrogenative coupling/annulation tandem reaction of glycine derivatives to 2,3-dihydrofuran is disclosed. This process involves the synergistic performance of organic-dye-mediated photoredox catalysis and acid catalysis. This reaction provides rapid and facile access to a series of valuable quinoline-fused lactones at room temperature under an air atmosphere. Moreover, the reaction could be performed on a 20 mmol scale, without obvious reduction of the yield.

Graphical abstract: Metal-free photocatalyzed aerobic oxidative Csp3–H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones

Supplementary files

Article information

Article type
Paper
Submitted
29 Jan 2018
Accepted
30 Apr 2018
First published
01 May 2018

Org. Biomol. Chem., 2018,16, 3816-3823

Metal-free photocatalyzed aerobic oxidative Csp3–H functionalization of glycine derivatives: one-step generation of quinoline-fused lactones

Y. He, B. Yan, H. Tao, Y. Zhang and Y. Li, Org. Biomol. Chem., 2018, 16, 3816 DOI: 10.1039/C8OB00240A

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