A TBAB-mediated brominative 5-exo-dig oxy-cyclization of 2-alkynylbenzamide is described here for the synthesis of isobenzofuran-1-imines and isobenzofuran derivatives at room temperature with a high efficiency and a broad reaction scope. The resulting isobenzofuran derivatives are also applied for synthesising various substituted isobenzofuran derivatives.
R. Wang, S. Yuan, J. Liu, J. Wu and G. Qiu, Org. Biomol. Chem., 2018, 16, 4501 DOI: 10.1039/C8OB00779A
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