Iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines: facile access to 5-(3-indolyl)oxazoles

Xiaozu Liu; Yuxiang Zhou; Guojun Chen; Zhongqin Yang; Qin Li; Peijun Liu

doi:10.1039/C8OB00833G

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Iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines: facile access to 5-(3-indolyl)oxazoles†

Xiaozu Liu,^a Yuxiang Zhou,^a Guojun Chen,^a Zhongqin Yang,^a Qin Li^a and Peijun Liu

*^a

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^a Pharmacy School, Zunyi Medical University, Zunyi 563006, P. R. China

Abstract

An iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines has been developed. This reaction enables the convenient synthesis of a variety of 5-(3-indolyl)oxazoles under mild conditions with broad functional group compatibility.

This article is part of the themed collection: Synthetic methodology in OBC

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DOI: https://doi.org/10.1039/C8OB00833G
Article type: Communication
Submitted: 09 Apr 2018
Accepted: 23 Apr 2018
First published: 26 Apr 2018

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Org. Biomol. Chem., 2018,16, 3572-3575

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Iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines: facile access to 5-(3-indolyl)oxazoles

X. Liu, Y. Zhou, G. Chen, Z. Yang, Q. Li and P. Liu, Org. Biomol. Chem., 2018, 16, 3572 DOI: 10.1039/C8OB00833G

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Organic & Biomolecular Chemistry

Iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines: facile access to 5-(3-indolyl)oxazoles†

Abstract

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Iodine-catalyzed oxidative annulation of 3-cyanoacetylindoles with benzylamines: facile access to 5-(3-indolyl)oxazoles

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