Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo

Chaochao Zhang; Lin Cheng; Gaopan Dong; Guangxi Han; Xingye Yang; Chunchao Tang; Xiang Li; Yubin Zhou; Lupei Du; Minyong Li

doi:10.1039/C8OB01192C

Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo†

Chaochao Zhang,‡^a Lin Cheng,‡^b Gaopan Dong,^a Guangxi Han,^a Xingye Yang,^a Chunchao Tang,^a Xiang Li,^a Yubin Zhou,

^c Lupei Du^a and Minyong Li

*^ad

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* Corresponding authors

^a Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China
E-mail: mli@sdu.edu.cn
Fax: +86-531-8838-2076
Tel: +86-531-8838-2076

^b Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China

^c Center for Translational Cancer Research, Institute of Biosciences and Technology, College of Medicine, Texas A&M University, Houston, TX 77030, USA

^d Shenzhen Research Institute, Shandong University, Shenzhen, Guangdong 518057, China

Abstract

To develop a photoactivatable bioluminescence imaging technique, a set of high and efficient photoactivatable substrates for Renilla luciferase has been well designed and synthesized. Surprisingly, all of them could release the free luciferin that presented robust bioluminescent signals ex vivo and in living animals after UV irradiation at 365 nm.

Organic & Biomolecular Chemistry

Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo†

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Novel photoactivatable substrates for Renilla luciferase imaging in vitro and in vivo

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