Direct C–OH/P(O)–H dehydration coupling forming phosphine oxides

Abstract

A t-BuONa-mediated C–OH/P(O)–H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcohols and P(O)–H compounds as the starting materials, providing an efficient alternative method for constructing sp³ C–P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed.