Issue 29, 2018
From the journal:

Organic & Biomolecular Chemistry

TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one†

Qi Liu,ab   Jie-Jie Liu,ab   Liang Cheng, ORCID logo *ab   Dong Wanga  and  Li Liu*ab  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: chengl@iccas.ac.cn, lliu@iccas.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Highly selective and catalyst-free tandem multi-functionalization of terminal alkynes was developed with 2-oxindoles and benzo-furan-2(3H)-one using TEMPO both as a radical promoter and a trapping reagent. This work expands the scope of the radical-cascade addition/trapping process of alkynes for the effective construction of various β-oxyl carbonyls in moderate to good yields.

Graphical abstract: TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

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Article information

DOI
https://doi.org/10.1039/C8OB01380B
Article type
Communication
Submitted
11 Jun 2018
Accepted
30 Jun 2018
First published
02 Jul 2018

Org. Biomol. Chem., 2018,16, 5228-5231

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TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

Q. Liu, J. Liu, L. Cheng, D. Wang and L. Liu, Org. Biomol. Chem., 2018, 16, 5228 DOI: 10.1039/C8OB01380B

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