Metal-free radical cascade chloromethylation of unactivated alkenes: synthesis of polychloro-substituted indolines

Abstract

The di- and trichloromethylation of N-allyl anilines was developed under metal-free conditions, leading to a variety of di- and trichloromethylated indolines in moderate to good yields. This procedure used the commercially available chemical feedstocks CH₂Cl₂, CHCl₃ and CCl₄ as the di- and trichloromethyl sources.