Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)

Yingkun Shi; Hongqing Xiao; Xiu-Hua Xu; Yangen Huang

doi:10.1039/C8OB02457J

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Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)†

Yingkun Shi,^a Hongqing Xiao,^a Xiu-Hua Xu^b and Yangen Huang

*^a

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* Corresponding authors

^a Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China
E-mail: hyg@dhu.edu.cn

^b Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China

Abstract

A novel transition metal-free decarboxylative fluoroalkylation of activated alkenes and C–H functionalization cascade process has been developed. This approach provides an efficient way to construct valuable 1,1-dimethyl-2,2,2-trifluoroethyl substituted oxindoles.

This article is part of the themed collection: Synthetic methodology in OBC

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DOI: https://doi.org/10.1039/C8OB02457J
Article type: Communication
Submitted: 02 Oct 2018
Accepted: 22 Oct 2018
First published: 22 Oct 2018

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Org. Biomol. Chem., 2018,16, 8472-8476

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Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)

Y. Shi, H. Xiao, X. Xu and Y. Huang, Org. Biomol. Chem., 2018, 16, 8472 DOI: 10.1039/C8OB02457J

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Organic & Biomolecular Chemistry

Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)†

Abstract

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Transition metal free decarboxylative fluoroalkylation of N-acrylamides with 3,3,3-trifluoro-2,2-dimethylpropanoic acid (TFDMPA)

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