Issue 3, 2018

Synthesis of substituted 4-hydroxyalkyl-quinoline derivatives by a three-component reaction using CuCl/AuCl as sequential catalysts

Abstract

A new method to construct 4-hydroxyalkyl-quinoline derivatives is described via Cu(I) and Au(I) sequential catalyzed cyclization of anilines with aldehyde derivatives and aliphatic alkynes, respectively. The three-component cascade reaction provides an efficient approach for easy access to various new quinoline-based derivatives and quinoline containing an aliphatic chain substituent at the 4-position with high yields.

Graphical abstract: Synthesis of substituted 4-hydroxyalkyl-quinoline derivatives by a three-component reaction using CuCl/AuCl as sequential catalysts

Supplementary files

Article information

Article type
Research Article
Submitted
26 Jul 2017
Accepted
13 Oct 2017
First published
16 Oct 2017

Org. Chem. Front., 2018,5, 434-441

Synthesis of substituted 4-hydroxyalkyl-quinoline derivatives by a three-component reaction using CuCl/AuCl as sequential catalysts

K. Jiang, J. Kang, Y. Jin and J. Lin, Org. Chem. Front., 2018, 5, 434 DOI: 10.1039/C7QO00637C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements