Iridium catalyzed fragmentation/cyclization of N-butynyl 4,4-dimethylisoxazolidine-3,5-diones: a unique access to multiply substituted pyrroles

Abstract

A unique protocol for the synthesis of substituted and fused pyrroles has been developed through the iridium catalyzed fragmentation/cyclization of related N-butynyl 4,4-dimethylisoxazolidine-3,5-diones in hot ethanol. Both the substitution pattern and electronic properties can affect the reaction rate and yield.