A highly efficient bifunctional guanidine catalyst was developed for the asymmetric cascade reaction between 2-nitrovinylphenols and azlactones. A wide variety of 3-aminodihydrocoumarin derivatives could be obtained in high yields (up to 99% yield) with excellent enantioselectivities (up to 99% ee) and diastereoselectivities (>19 : 1 dr).
S. Ruan, X. Lin, L. Xie, L. Lin, X. Feng and X. Liu, Org. Chem. Front., 2018, 5, 32 DOI: 10.1039/C7QO00768J
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