Photoredox 1,2-dicarbofunctionalization of unactivated alkenes via tandem radical difluoroalkylation and alkynyl migration

Abstract

Visible-light-mediated tandem radical difluoroalkylation and alkynylation of unactivated alkenes is described in this communication. The process comprises a mild C–C bond activation via intramolecular 1,4-alkynyl migration. The general and elegant protocol can serve as a straightforward access route to obtain a wide range of synthetically valuable difluoroalkylated linear alkynyl ketones under mild reaction conditions.