CBr4-mediated cross-coupling reactions of α-amino carbonyl compounds with alcohols and thiols to build C–O and C–S bonds, respectively

Xingxing Liu; Jinghong Pu; Xinliang Luo; Xinfeng Cui; Zhaoyang Wu; Guosheng Huang

doi:10.1039/C7QO00830A

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CBr₄-mediated cross-coupling reactions of α-amino carbonyl compounds with alcohols and thiols to build C–O and C–S bonds, respectively†

Xingxing Liu,^a Jinghong Pu,^a Xinliang Luo,^a Xinfeng Cui,^a Zhaoyang Wu^b and Guosheng Huang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou 730000, China
E-mail: hgs@lzu.edu.cn

^b The Environmental Protection Agency of Rudong Coastal Economic Development Zone, Nantong 226400, China

Abstract

A novel and efficient CBr₄-mediated oxidative cross-coupling reaction of α-amino carbonyl compounds with alcohols and thiols to build C–O and C–S bonds, respectively, has been developed. The reactions were realized under mild and transition-metal-free conditions via using CBr₄ instead of complex catalyst systems.

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Article information

DOI: https://doi.org/10.1039/C7QO00830A
Article type: Research Article
Submitted: 12 Sep 2017
Accepted: 02 Oct 2017
First published: 10 Oct 2017

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Org. Chem. Front., 2018,5, 361-365

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CBr₄-mediated cross-coupling reactions of α-amino carbonyl compounds with alcohols and thiols to build C–O and C–S bonds, respectively

X. Liu, J. Pu, X. Luo, X. Cui, Z. Wu and G. Huang, Org. Chem. Front., 2018, 5, 361 DOI: 10.1039/C7QO00830A

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