Issue 4, 2018

Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids

Abstract

The Brønsted/Lewis acid catalyzed reaction of pyrrolidone, piperidone and isoindolinone derivatives tethered to α,β-unsaturated ketones or aldehydes afforded exclusively polyfunctionalized 1,3-oxazines with high diastereoselectivities and in high yields.

Graphical abstract: Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids

Supplementary files

Article information

Article type
Research Article
Submitted
29 Sep 2017
Accepted
25 Oct 2017
First published
26 Oct 2017

Org. Chem. Front., 2018,5, 566-570

Highly diastereoselective access to polyfunctionalized 1,3-oxazines promoted by Brønsted/Lewis acids

C. Peter, P. Geoffroy and M. Miesch, Org. Chem. Front., 2018, 5, 566 DOI: 10.1039/C7QO00891K

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