Issue 6, 2018

Co(iii)-Catalyzed N-chloroamide-directed C–H activation for 3,4-dihydroisoquinolone synthesis

Abstract

The synthesis of 3,4-dihydroisoquinolone via Co(III)-catalyzed C–H activation has been achieved for the first time. N-Chloroamides as a C–H activation directing synthon react effectively with alkenes at room temperature, enabling the incorporation of diverse reactive functionalities and substitution patterns into the target heterocycles.

Graphical abstract: Co(iii)-Catalyzed N-chloroamide-directed C–H activation for 3,4-dihydroisoquinolone synthesis

Supplementary files

Article information

Article type
Research Article
Submitted
16 Dec 2017
Accepted
04 Jan 2018
First published
05 Jan 2018

Org. Chem. Front., 2018,5, 994-997

Co(III)-Catalyzed N-chloroamide-directed C–H activation for 3,4-dihydroisoquinolone synthesis

X. Yu, K. Chen, Q. Wang, W. Zhang and J. Zhu, Org. Chem. Front., 2018, 5, 994 DOI: 10.1039/C7QO01124E

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