Issue 10, 2018

Copper/amine-catalyzed formal regioselective [3 + 2] cycloaddition of an α,β-unsaturated O-acetyl oxime with enals

Abstract

A novel copper/amine co-catalyzed formal regioselective [3 + 2] cycloaddition reaction of an O-acyl oxime with α,β-unsaturated aldehydes is developed. This novel transformation provided an efficient protocol for the assembly of multifunctionalized pyrroles with good yields and diverse functional group tolerance.

Graphical abstract: Copper/amine-catalyzed formal regioselective [3 + 2] cycloaddition of an α,β-unsaturated O-acetyl oxime with enals

Supplementary files

Article information

Article type
Research Article
Submitted
26 Feb 2018
Accepted
27 Mar 2018
First published
29 Mar 2018

Org. Chem. Front., 2018,5, 1698-1701

Copper/amine-catalyzed formal regioselective [3 + 2] cycloaddition of an α,β-unsaturated O-acetyl oxime with enals

Y. Xie, Y. Li, X. Chen, Y. Liu and W. Zhang, Org. Chem. Front., 2018, 5, 1698 DOI: 10.1039/C8QO00204E

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