Ru(II)-Catalyzed C6-selective C–H amidation of 2-pyridones

Lei Zhang; Xiangyun Zheng; Jinkang Chen; Kang Cheng; Licheng Jin; Xinpeng Jiang; Chuanming Yu

doi:10.1039/C8QO00795K

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Ru(ii)-Catalyzed C6-selective C–H amidation of 2-pyridones†

Lei Zhang,^a Xiangyun Zheng,^a Jinkang Chen,^a Kang Cheng,^a Licheng Jin,^a Xinpeng Jiang

*^a and Chuanming Yu

*^ab

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* Corresponding authors

^a College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China
E-mail: ycm@zjut.edu.cn

^b Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China

Abstract

Ru(II)-Catalyzed C6 site-selective amidation of 2-pyridones with 1,4,2-dioxazol-5-ones has been developed. The reaction occurred with a low catalyst loading and broad substrate scope under mild conditions, affording desired products in up to 98% yields within a short time.

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Article information

DOI: https://doi.org/10.1039/C8QO00795K
Article type: Research Article
Submitted: 30 Jul 2018
Accepted: 12 Sep 2018
First published: 13 Sep 2018

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Org. Chem. Front., 2018,5, 2969-2973

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Ru(II)-Catalyzed C6-selective C–H amidation of 2-pyridones

L. Zhang, X. Zheng, J. Chen, K. Cheng, L. Jin, X. Jiang and C. Yu, Org. Chem. Front., 2018, 5, 2969 DOI: 10.1039/C8QO00795K

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Ru(ii)-Catalyzed C6-selective C–H amidation of 2-pyridones†

Abstract

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Ru(II)-Catalyzed C6-selective C–H amidation of 2-pyridones

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