A NaSO2CF3/NaBrO3-mediated bromotrifluoromethylation of enyne via free-radical cascade processes

Xiao-Jie Shang; Dong Liu; Zhong-Quan Liu

doi:10.1039/C8QO00847G

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A NaSO₂CF₃/NaBrO₃-mediated bromotrifluoromethylation of enyne via free-radical cascade processes†

Xiao-Jie Shang,*^a Dong Liu^b and Zhong-Quan Liu

*^b

Author affiliations

* Corresponding authors

^a College of Resources and Environment, Gansu Agricultural University, Lanzhou 730070, China
E-mail: shangxiaojie@yahoo.cn

^b State Key Laboratory Cultivation Base for TCM Quality and Efficacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
E-mail: liuzq@njucm.edu.cn

Abstract

A NaBrO₃-triggered free radical bromotrifluoromethylation of enynes with NaSO₂CF₃ was developed. It provides a facile access to a wide range of bromotrifluoromethylated five- and six-membered heterocycles. A spin trapping experiment together with electron spin resonance (ESR) studies indicated it should be conducted through a free radical process.

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Article information

DOI: https://doi.org/10.1039/C8QO00847G
Article type: Research Article
Submitted: 10 Aug 2018
Accepted: 30 Aug 2018
First published: 30 Aug 2018

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Org. Chem. Front., 2018,5, 2856-2859

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A NaSO₂CF₃/NaBrO₃-mediated bromotrifluoromethylation of enyne via free-radical cascade processes

X. Shang, D. Liu and Z. Liu, Org. Chem. Front., 2018, 5, 2856 DOI: 10.1039/C8QO00847G

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