Issue 24, 2018

Nucleophile-controlled mono- and bis-phosphonation of amino-2-en-1-ones via catalyst-free C(sp3)–N bond cleavage

Abstract

A catalyst-free mono- and bis-phosphonation of amino-2-en-1-ones via C(sp3)–N bond cleavage is described. This reaction proceeds through an interaction of substrates in the absence of any external catalyst or additive, and under air conditions. The selectivity of the mono-phosphonation and bis-phosphonation was controlled by the phosphorus nucleophiles with their nucleophilicities.

Graphical abstract: Nucleophile-controlled mono- and bis-phosphonation of amino-2-en-1-ones via catalyst-free C(sp3)–N bond cleavage

Supplementary files

Article information

Article type
Research Article
Submitted
07 Sep 2018
Accepted
05 Nov 2018
First published
07 Nov 2018

Org. Chem. Front., 2018,5, 3548-3552

Nucleophile-controlled mono- and bis-phosphonation of amino-2-en-1-ones via catalyst-free C(sp3)–N bond cleavage

L. Huang, Z. Zhang, K. Jie, Y. Wang, Z. Fu, S. Guo and H. Cai, Org. Chem. Front., 2018, 5, 3548 DOI: 10.1039/C8QO00975A

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