Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9

Meeri Käkelä; Pauliina Luoto; Tapio Viljanen; Helena Virtanen; Heidi Liljenbäck; Sirpa Jalkanen; Juhani Knuuti; Anne Roivainen; Xiang-Guo Li

doi:10.1039/C7RA12423F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Adventures in radiosynthesis of clinical grade [⁶⁸Ga]Ga-DOTA-Siglec-9†

Meeri Käkelä,^a Pauliina Luoto,^b Tapio Viljanen,^a Helena Virtanen,^a Heidi Liljenbäck,^ac Sirpa Jalkanen,^d Juhani Knuuti,^ab Anne Roivainen

*^abc and Xiang-Guo Li

*^ae

Author affiliations

* Corresponding authors

^a Turku PET Centre, University of Turku, FI-20521 Turku, Finland
E-mail: xiali@utu.fi, anne.roivainen@utu.fi

^b Turku PET Centre, Turku University Hospital, FI-20521 Turku, Finland

^c Turku Center for Disease Modeling, University of Turku, FI-20014, Turku, Finland

^d MediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, FI-20014 Turku, Finland

^e Turku PET Centre, Åbo Akademi University, FI-20521 Turku, Finland

Abstract

We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1,4,7,0-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([⁶⁸Ga]Ga-DOTA-Siglec-9), the first radiopharmaceutical for positron emission tomography imaging of vascular adhesion protein 1.

Download options Please wait...

Supplementary files

Supplementary information PDF (353K)

Article information

DOI: https://doi.org/10.1039/C7RA12423F
Article type: Paper
Submitted: 20 Nov 2017
Accepted: 08 Feb 2018
First published: 20 Feb 2018
This article is Open Access

Download Citation

RSC Adv., 2018,8, 8051-8056

Permissions

Request permissions

Adventures in radiosynthesis of clinical grade [⁶⁸Ga]Ga-DOTA-Siglec-9

M. Käkelä, P. Luoto, T. Viljanen, H. Virtanen, H. Liljenbäck, S. Jalkanen, J. Knuuti, A. Roivainen and X. Li, RSC Adv., 2018, 8, 8051 DOI: 10.1039/C7RA12423F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

RSC Advances