A unimolecular theranostic system with H2O2-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells

Xiaoying Gao; Jie Cao; Yinuo Song; Xiao Shu; Jianzhao Liu; Jing Zhi Sun; Bin Liu; Ben Zhong Tang

doi:10.1039/C8RA01185K

A unimolecular theranostic system with H₂O₂-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells†

Xiaoying Gao,^a Jie Cao,^a Yinuo Song,^a Xiao Shu,^a Jianzhao Liu,*^a Jing Zhi Sun,

^a Bin Liu

*^b and Ben Zhong Tang*^acd

Author affiliations

* Corresponding authors

^a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: liujz@zju.edu.cn

^b Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, Singapore
E-mail: cheliub@nus.edu.sg

^c Department of Chemistry, Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

^d SCUT-HKUST Joint Research Laboratory, Guangdong Innovative Research Team, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, China

Abstract

A theranostic drug delivery system composed of tetraphenyl-ethene (AIEgen), benzyl boronic ester (trigger), and doxorubicin (drug) was designed and synthesized; its utilities for cell imaging, drug delivery tracking, and cancer cell cytociding were evaluated.

This article is part of the themed collection: Editors’ collection: Fluorescent Sensors

Supplementary files

Article information

DOI: https://doi.org/10.1039/C8RA01185K
Article type: Paper
Submitted: 07 Feb 2018
Accepted: 14 Mar 2018
First published: 20 Mar 2018
This article is Open Access

Download Citation

RSC Adv., 2018,8, 10975-10979

Permissions

Request permissions

A unimolecular theranostic system with H₂O₂-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells

X. Gao, J. Cao, Y. Song, X. Shu, J. Liu, J. Z. Sun, B. Liu and B. Z. Tang, RSC Adv., 2018, 8, 10975 DOI: 10.1039/C8RA01185K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

RSC Advances