Issue 19, 2018, Issue in Progress

Friedel–Crafts alkylation reaction with fluorinated alcohols as hydrogen-bond donors and solvents

Abstract

An effective and clean FC alkylation of indoles and electron-rich arenes with β-nitroalkenes in HFIP was reported. The desired products are formed rapidly in excellent yields under mild conditions without the need for any additional catalysts or reagents. Further, this methodology can be applied to one-pot synthesis of biologically active tryptamine derivatives.

Graphical abstract: Friedel–Crafts alkylation reaction with fluorinated alcohols as hydrogen-bond donors and solvents

Supplementary files

Article information

Article type
Paper
Submitted
13 Feb 2018
Accepted
05 Mar 2018
First published
13 Mar 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 10314-10317

Friedel–Crafts alkylation reaction with fluorinated alcohols as hydrogen-bond donors and solvents

R. Tang, T. Milcent and B. Crousse, RSC Adv., 2018, 8, 10314 DOI: 10.1039/C8RA01397G

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