Issue 24, 2018, Issue in Progress
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RSC Advances

A simple two-photon turn-on fluorescent probe for the selective detection of cysteine based on a dual PeT/ICT mechanism†

Xiani Chen,‡a   Hang Xu,‡a   Shengnan Ma,a   Hongjuan Tong,ab   Kaiyan Lou ORCID logo *a  and  Wei Wang ORCID logo *ac  

* Corresponding authors

a Shanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
E-mail: kylou@ecust.edu.cn

b School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi'an 712046, China

c Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131-0001, USA
E-mail: wwang@unm.edu

Abstract

Herein, a simple two-photon turn-on fluorescent probe, N-(6-acyl-2-naphthayl)-maleimide (1), based on a dual PeT/ICT quenching mechanism is reported for the highly sensitive and selective detection of cysteine (Cys) over other biothiols. The probe was applied in the two-photon imaging of Cys in cultured HeLa cells, excited by a near-infrared laser at 690 nm.

Graphical abstract: A simple two-photon turn-on fluorescent probe for the selective detection of cysteine based on a dual PeT/ICT mechanism

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Article information

DOI
https://doi.org/10.1039/C8RA02138D
Article type
Paper
Submitted
10 Mar 2018
Accepted
29 Mar 2018
First published
10 Apr 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 13388-13392

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A simple two-photon turn-on fluorescent probe for the selective detection of cysteine based on a dual PeT/ICT mechanism

X. Chen, H. Xu, S. Ma, H. Tong, K. Lou and W. Wang, RSC Adv., 2018, 8, 13388 DOI: 10.1039/C8RA02138D

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