Determination of solubility, stability and degradation kinetics of morin hydrate in physiological solutions

Abstract

Natural drugs have emerged as potential alternatives to synthetic drugs to avoid their toxic effects. Morin hydrate (MH) is a natural therapeutic agent, obtained from Maclura pomifera, Maclura tinctoria and Psidium guajava. Solubility and degradation kinetics of morin hydrate in different physiological media, namely, 0.1 N HCl (pH 1.2), sodium acetate buffer (pH 5.0), water (pH 7.0), phosphate buffer saline (pH 7.4) and tris base (pH 9.0), were investigated via classical spectroscopic methods. Stability studies of MH were performed to determine the effect of different pH media, temperature (room and freeze) and light on the degradation kinetics. Solubility and stability of MH varied significantly in different biological media and storage conditions. Solubility of MH was pH-dependent and increased with the increase in pH. Degradation kinetics and regression values (r²) values were calculated from the linear fitted models of zero, first and second order kinetics.