Synthesis of switchable intelligent molecularly imprinted polymers with selective adsorption of ethyl carbamate and their application in electrochemical sensor analysis

Abstract

A cyclodextrin aldehyde based molecularly imprinted polymer with thermally responsive Diels–Alder (DA) linkages of grafted furan-type dienes was polymerized. The synthesized DA-MIP has dienophile characteristics and the specific absorption of ethyl carbamate (EC) can be switched on or off simply by thermal adjustment to 130 °C and 60 °C, respectively. The imprinting factors (α) of the MIP and rDA-MIP to EC were 6.2 and 5.0, and the selection factors (β) were 5.2 and 4.0, respectively. The restoration of the molecular target ratio was 88%, as determined by absorption and desorption experiments. The thermal restoration ratio, determined by thermal cycling experiments, was 78%. A new electrochemical sensor was prepared using the DA-MIP and its responsiveness for detecting trace amounts of EC was investigated. The results indicate that the electrode response has good affinity and excellent specific recognition performance for template molecular chemicals.