Issue 45, 2018, Issue in Progress

Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana

Abstract

Six new guaiane dimers, xyloplains A–F (1–6), with connecting patterns through two direct C–C bonds (C-1 to C-3′, C-2 to C-1′), were isolated from the roots of Xylopia vielana. Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compounds 2 and 6 exhibited moderate inhibitory activity against the production of nitric oxide with IC50 value of 34.5 and 31.1 μM, respectively, in RAW264.7 cells stimulated by LPS.

Graphical abstract: Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana

Supplementary files

Article information

Article type
Paper
Submitted
22 May 2018
Accepted
22 Jun 2018
First published
18 Jul 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 25719-25724

Xyloplains A–F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana

Y. Xie, W. Zhang, S. Zhu, T. Cheng, G. Wu, I. Muhammad, S. Yan, Y. Zhang, H. Jin and W. Zhang, RSC Adv., 2018, 8, 25719 DOI: 10.1039/C8RA04356F

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