Issue 47, 2018, Issue in Progress

Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities

Abstract

We demonstrated an easy-to-use strategy, instead of the tedious cyclization of the peptide backbone, to constrain the freedom of an RGD (arginine, glycine, aspartic acid) sequence with gold nanorods. We further constructed a multifunctional therapeutic agent which showed targeting, application in two-photon photoluminescence imaging, and near-infrared photothermal ability, suggesting the potential of this novel strategy in the development of RGD-containing drugs for biomedical applications.

Graphical abstract: Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities

Supplementary files

Article information

Article type
Paper
Submitted
23 May 2018
Accepted
10 Jul 2018
First published
25 Jul 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 26517-26522

Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities

L. Xie, X. Zhi, N. Xiao, C. Fang and C. Yan, RSC Adv., 2018, 8, 26517 DOI: 10.1039/C8RA04379E

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