Issue 60, 2018, Issue in Progress
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RSC Advances

Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction†

Daria S. Novikova, ORCID logo *a   Tatyana A. Grigoreva, ORCID logo a   Andrey A. Zolotarev, ORCID logo b   Alexander V. Garabadzhiua  and  Vyacheslav G. Tribulovich ORCID logo a  

* Corresponding authors

a Laboratory of Molecular Pharmacology, Saint Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26, Saint Petersburg 190013, Russia
E-mail: dc.novikova@gmail.com

b Department of Crystallography, Saint Petersburg State University, per. Dekabristov 16, Saint Petersburg 199155, Russia

Abstract

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C–H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

Graphical abstract: Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction

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Article information

DOI
https://doi.org/10.1039/C8RA07576J
Article type
Paper
Submitted
11 Sep 2018
Accepted
02 Oct 2018
First published
10 Oct 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 34543-34551

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Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction

D. S. Novikova, T. A. Grigoreva, A. A. Zolotarev, Alexander V. Garabadzhiu and V. G. Tribulovich, RSC Adv., 2018, 8, 34543 DOI: 10.1039/C8RA07576J

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