Issue 69, 2018, Issue in Progress
From the journal:

RSC Advances

Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines†

Maya Millera  and  Edit Y. Tshuva ORCID logo *a  

* Corresponding authors

a Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel
E-mail: edit.tshuva@mail.huji.ac.il

Abstract

A tetrakis(phenolato) Ti(IV) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a beneficial activity of both enantiomers rendering enantiomeric resolution unnecessary.

Graphical abstract: Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines

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Article information

DOI
https://doi.org/10.1039/C8RA08925F
Article type
Paper
Submitted
28 Oct 2018
Accepted
21 Nov 2018
First published
27 Nov 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 39731-39734

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Racemic vs. enantiopure inert Ti(IV) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines

M. Miller and E. Y. Tshuva, RSC Adv., 2018, 8, 39731 DOI: 10.1039/C8RA08925F

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