Issue 11, 2018

Recent advances in biomolecule immobilization based on self-assembly: organic–inorganic hybrid nanoflowers and metal–organic frameworks as novel substrates

Abstract

In the past few years, the immobilization of biomolecules on hybrid nanoflowers and metal–organic frameworks (MOFs) via self-assembly synthesis has received much attention due to its simplicity, high efficiency, and a bright prospect of enhancing the stability, activity and even selectivity of biomolecules compared to conventional immobilization methods. In the synthesis of organic–inorganic hybrid nanoflowers, biomolecules used as organic components are simply mixed with metal ions which act as inorganic components to form flower-like nanocomposites, while in the self-assembly process of encapsulating biomolecules in MOFs (biomolecule@MOF composites), the biomolecules just need to be added to the precursor mixtures of MOFs, in which the biomolecules are therefore embedded in MOF crystals with small pores. In this review, we focus on the recent advances of these composites, especially in the synthesis strategies, mechanism and applications in biosensors, biomedicine, pollutant disposal, and industrial biocatalysis, and future perspectives are discussed as well.

Graphical abstract: Recent advances in biomolecule immobilization based on self-assembly: organic–inorganic hybrid nanoflowers and metal–organic frameworks as novel substrates

Article information

Article type
Review Article
Submitted
24 Dec 2017
Accepted
02 Feb 2018
First published
02 Feb 2018

J. Mater. Chem. B, 2018,6, 1581-1594

Recent advances in biomolecule immobilization based on self-assembly: organic–inorganic hybrid nanoflowers and metal–organic frameworks as novel substrates

Z. Lei, C. Gao, L. Chen, Y. He, W. Ma and Z. Lin, J. Mater. Chem. B, 2018, 6, 1581 DOI: 10.1039/C7TB03310A

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