Issue 15, 2018

Core–shell TaOx@MnO2 nanoparticles as a nano-radiosensitizer for effective cancer radiotherapy

Abstract

Improving tumor oxygenation and concentrating X-ray radiation energy inside the tumor have received considerable attention in cancer radiotherapy. Herein, core–shell tantalum oxide@manganese dioxide (TaOx@MnO2) nanostructures are prepared as an efficient radiosensitizer for enhancing radiotherapy (RT). In these nanostructures, the TaOx core serves as a RT sensitizer that efficiently concentrates X-ray radiation energy inside the tumor, while the MnO2 shell may trigger the decomposition of endogenous H2O2 in the tumor microenvironment (TME) to generate oxygen and overcome hypoxia-associated radiation resistance. In vitro and in vivo experiments demonstrated that the synthesized TaOx@MnO2-PEG nanostructures could accomplish an excellent synergistic radiotherapy sensitization effect. Furthermore, TaOx@MnO2-PEG nanoparticles could also serve as promising agents for MR/CT dual-modal imaging. In brief, our study highlights a new type of multifunctional radiosensitizer agent to enhance radiotherapy treatment by means of simultaneously concentrating radiation energy inside tumors and overcoming tumor hypoxia, promising for applications in tumor radiotherapy.

Graphical abstract: Core–shell TaOx@MnO2 nanoparticles as a nano-radiosensitizer for effective cancer radiotherapy

Supplementary files

Article information

Article type
Paper
Submitted
09 Jan 2018
Accepted
07 Mar 2018
First published
07 Mar 2018

J. Mater. Chem. B, 2018,6, 2250-2257

Core–shell TaOx@MnO2 nanoparticles as a nano-radiosensitizer for effective cancer radiotherapy

F. Gong, J. Chen, X. Han, J. Zhao, M. Wang, L. Feng, Y. Li, Z. Liu and L. Cheng, J. Mater. Chem. B, 2018, 6, 2250 DOI: 10.1039/C8TB00070K

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