Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY

Mengliang Zhu; Peipei Xing; Yabin Zhou; Lei Gong; Jinghui Zhang; Dongdong Qi; Yongzhong Bian; Hongwu Du; Jianzhuang Jiang

doi:10.1039/C8TB00883C

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Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY†

Mengliang Zhu,^a Peipei Xing,^a Yabin Zhou,^b Lei Gong,^a Jinghui Zhang,^a Dongdong Qi,^a Yongzhong Bian,

*^a Hongwu Du*^b and Jianzhuang Jiang

*^a

Author affiliations

* Corresponding authors

^a Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, Department of Chemistry, University of Science and Technology Beijing, Beijing 100083, China
E-mail: yzbian@ustb.edu.cn, jianzhuang@ustb.edu.cn

^b Department of Biology, University of Science and Technology Beijing, Beijing 100083, China
E-mail: hongwudu@ustb.edu.cn

Abstract

BODIPY-based probes were developed for the ratiometric fluorescence detection of pH values. They showed high sensitivity under acidic conditions via a protonation-modulated ICT mechanism and could selectively stain lysosomes, and thus could be applied for imaging and detecting abnormal pH decreases in live cells.

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Article information

DOI: https://doi.org/10.1039/C8TB00883C
Article type: Communication
Submitted: 01 Apr 2018
Accepted: 18 Jun 2018
First published: 21 Jun 2018

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J. Mater. Chem. B, 2018,6, 4422-4426

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Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY

M. Zhu, P. Xing, Y. Zhou, L. Gong, J. Zhang, D. Qi, Y. Bian, H. Du and J. Jiang, J. Mater. Chem. B, 2018, 6, 4422 DOI: 10.1039/C8TB00883C

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Journal of Materials Chemistry B

Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY†

Abstract

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Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY

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