Issue 43, 2018

A Pd corolla–human serum albumin–indocyanine green nanocomposite for photothermal/photodynamic combination therapy of cancer

Abstract

In this work, a novel nanoplatform based on Pd corolla–human serum albumin–indocyanine green (PdCs–HSA–ICG) was developed for cancer photothermal/photodynamic combination therapy. Pd corollas (denoted as PdCs) with good near-infrared photothermal conversion efficiency (η ≈ 37%) were first prepared and modified with human serum albumin (HSA) and indocyanine green (ICG) to get the PdCs–HSA–ICG nanocomposite. The prepared PdCs–HSA–ICG not only improves the colloid and thermal stability of ICG, but also shows a higher temperature increase than that of PdCs and free ICG as well as a comparable singlet oxygen (1O2) generation capability to that of free ICG. Upon single 808 nm laser irradiation, the photothermal (PTT)/photodynamic (PDT) combined therapeutic efficacy of PdCs–HSA–ICG at both cellular and animal levels was superior to PdCs–HSA (PTT) or free ICG (PTT and PDT), respectively. Thus, the designed PdCs–HSA–ICG nanocomposite holds great potential as a new class of photosensitive agent for cancer phototherapy.

Graphical abstract: A Pd corolla–human serum albumin–indocyanine green nanocomposite for photothermal/photodynamic combination therapy of cancer

Supplementary files

Article information

Article type
Paper
Submitted
19 Jul 2018
Accepted
28 Sep 2018
First published
01 Oct 2018

J. Mater. Chem. B, 2018,6, 6969-6976

A Pd corolla–human serum albumin–indocyanine green nanocomposite for photothermal/photodynamic combination therapy of cancer

D. Sun, Y. Huang, X. Zhang, J. Peng, J. Li, J. Ming, J. Wei, X. Chen and N. Zheng, J. Mater. Chem. B, 2018, 6, 6969 DOI: 10.1039/C8TB01874J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements