CO2-Acidolysis of iminoboronate ester based polymersomes†
Abstract
Due to the very weak acidity of CO2 in water, it is highly interesting to fabricate CO2-responsive polymersomes which have both CO2-protonatable tertiary amines and CO2-hydrolyzable iminoboronate-linked drugs. Upon CO2 addition, amine protonation and iminoboronate hydrolysis simultaneously occur, leading to prominent vesicle disassembly and a tunable release feature.