Issue 23, 2019
From the journal:

Analyst

Surface-enhanced Raman spectroscopy (SERS) characterisation of abasic sites in DNA duplexes†

Luca Guerrini ORCID logo *a  and  Ramon A. Alvarez-Puebla ORCID logo *ab  

* Corresponding authors

a Department of Physical and Inorganic Chemistry and EMaS, Universitat Rovira I Virgili, Carrer de Marcel.lí Domingo s/n, 43007 Tarragona, Spain
E-mail: luca.guerrini@urv.cat, ramon.alvarez@urv.cat

b ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Spain

Abstract

In this study, direct surface-enhanced Raman scattering (SERS) spectroscopy is used as an exquisite nano-optical tool for ultrasensitive structural characterisation of abasic sites in DNA. In addition, the conformational discrimination (intra- vs. extra-helical) of the nucleobase opposite to the abasic site was also achieved.

Graphical abstract: Surface-enhanced Raman spectroscopy (SERS) characterisation of abasic sites in DNA duplexes

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Article information

DOI
https://doi.org/10.1039/C9AN02040C
Article type
Communication
Submitted
11 Oct 2019
Accepted
04 Nov 2019
First published
05 Nov 2019

Analyst, 2019,144, 6862-6865

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Surface-enhanced Raman spectroscopy (SERS) characterisation of abasic sites in DNA duplexes

L. Guerrini and R. A. Alvarez-Puebla, Analyst, 2019, 144, 6862 DOI: 10.1039/C9AN02040C

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