Molecular chaperone prefoldin-assisted biosynthesis of gold nanoparticles with improved size distribution and dispersion

Yovita Djohan; Tomoki Azukizawa; Patmawati; Kotaro Sakai; Yuki Yano; Fumiya Sato; Ryoji Takahashi; Masafumi Yohda; Mizuo Maeda; Noriho Kamiya; Tamotsu Zako

doi:10.1039/C8BM01026A

Molecular chaperone prefoldin-assisted biosynthesis of gold nanoparticles with improved size distribution and dispersion†

Yovita Djohan,

‡^a Tomoki Azukizawa,‡^b Patmawati,^a Kotaro Sakai,^cd Yuki Yano,^b Fumiya Sato,^b Ryoji Takahashi,^b Masafumi Yohda,

^c Mizuo Maeda,^d Noriho Kamiya

^a and Tamotsu Zako

*^bd

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* Corresponding authors

^a Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Motooka 744, Nishi-ku, Fukuoka 819-0395, Japan

^b Department of Chemistry and Biology, Graduate School of Science and Engineering, Ehime University, 2-5 Bunkyo, Matsuyama, Ehime 790-8577, Japan
E-mail: zako.tamotsu.us@ehime-u.ac.jp

^c Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan

^d Bioengineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Abstract

Here we report a novel aspect of molecular chaperone prefoldin (PFD) as a biomaterial in the biocatalytic synthesis of gold nanoparticles (AuNPs) using glycerol dehydrogenase (GLD). We found that PFD could inhibit the aggregation of AuNPs during the biosynthesis, leading to the formation of AuNPs with controlled size distribution.

Biomaterials Science

Molecular chaperone prefoldin-assisted biosynthesis of gold nanoparticles with improved size distribution and dispersion†

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Molecular chaperone prefoldin-assisted biosynthesis of gold nanoparticles with improved size distribution and dispersion

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