A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and chimeric derivatives†
Radell
Echemendía, 
ab
Alexander F.
de la Torre,
ac
Arlene G.
Corrêa,
a
Daniel G.
Rivera
*b
and
Márcio W.
Paixão
*a
ab
Alexander F.
de la Torre,
ac
Arlene G.
Corrêa,
a
Daniel G.
Rivera
*b
and
Márcio W.
Paixão
*a
Abstract
A stereoselective multicomponent approach leading to a novel class of pentasubstituted tetrahydropyridines is described. Variation of the components enabled the incorporation of peptide, sugar and steroid moieties to access chimeric derivatives. DFT calculations provide insights about the unprecedented high diastereoselectivity of the MCR.
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