A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

Jingli Hou; Haiyan He; Saipeng Huang; Meng Qian; Jie Wang; Xiaoli Tan; Guifang Han; Yuguang Song; Zhelong Xu; Yangping Liu

doi:10.1039/C8CC07304J

A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury†

Jingli Hou,^a Haiyan He,^b Saipeng Huang,^c Meng Qian,^a Jie Wang,^b Xiaoli Tan,^a Guifang Han,^a Yuguang Song,*^a Zhelong Xu*^b and Yangping Liu

*^a

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* Corresponding authors

^a Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, P. R. China
E-mail: liuyangping@tmu.edu.cn, songyuguang@tmu.edu.cn

^b Department of Physiology & Pathophysiology, Tianjin Medical University, Tianjin 300070, P. R. China
E-mail: Zxu@tmu.edu.cn

^c School of Chemical Engineering, Northwest University, Xi’an, P. R. China

Abstract

A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate, enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells and isolated rat hearts.

Chemical Communications

A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury†

Abstract

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A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

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