Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence for in vivo real-time monitoring of drug toxicity

Yufu Tang; Yuanyuan Li; Zhen Wang; Feng Pei; Xiaoming Hu; Yu Ji; Xiang Li; Hui Zhao; Wenbo Hu; Xiaomei Lu; Quli Fan; Wei Huang

doi:10.1039/C8CC08413K

Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence for in vivo real-time monitoring of drug toxicity†

Yufu Tang,‡§^a Yuanyuan Li,‡^a Zhen Wang,^a Feng Pei,^b Xiaoming Hu,^a Yu Ji,^a Xiang Li,^a Hui Zhao,^a Wenbo Hu,

^a Xiaomei Lu,^b Quli Fan

*^a and Wei Huang^abc

Author affiliations

* Corresponding authors

^a Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications (NUPT), Nanjing 210023, China
E-mail: iamqlfan@njupt.edu.cn

^b Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (Nanjing Tech), Nanjing 211816, China

^c Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), Xi’an 710072, China

Abstract

An activatable organic semiconducting nanoprobe that specifically turns on its second near-infrared window fluorescence upon being exposed to nitric oxide stimuli was developed for in vivo, in situ, real-time and high-spatial-resolution mapping of drug-induced hepatotoxicity.

Chemical Communications

Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence for in vivo real-time monitoring of drug toxicity†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence for in vivo real-time monitoring of drug toxicity

Social activity

Search articles by author

Spotlight

Advertisements